Bioinformatics & Personalized Medicine

Bioinformatics

Advanced Molecular Detection (AMD)

EMS supported the Office of Infectious Diseases through a contract for bioinformatics and advanced molecular detection. Our employees assisted 8 federal Principal Investigators with more than 11 different projects in the Division of High-Consequence Pathogens and Pathology – Poxvirus & Rabies Research Branch, Division of Viral Diseases – Measles, Mumps, Rubella, and Herpesvirus Laboratory Branch, Division of Viral Diseases – Pathogen Discovery Program, Division of Viral Hepatitis, Division of Parasitic Diseases and Malaria -Malaria Branch.

One of our senior bioinformaticians presented the results of their work entitled “Rapid Identification of Monkeypox Virus using Tandem Repeats with Insertion, Deletion and SNPs” at the 1st ASM Conference on Rapid Next-Generation Sequencing and Bioinformatic Pipelines for Enhanced Molecular Epidemiologic Investigation of Pathogens in Washington, DC in September 2015. To see the results of this work, please find the poster presentation attached below.

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Rapid Identification of Monkeypox Virus using Tandem Repeats with Insertion, Deletion and SNPs

Produced by Xiangxue Guo, Ph.D. on behalf of the Centers for Disease Control and Prevention for the American Society for Microbiology's 1st Conference on Rapid Next-Generation Sequencing and Bioinformatic Pipelines for Enhanced Molecular Epidemiologic Investigation of Pathogens in Washington, DC in September 2015.

EMS provided vital support toward the development of Global Hepatitis & Surveillance Technology (GHOST) where the genetic makeup each patients Hepatitis C viruses are registered in a patient database. GHOST then combines all the information in its database to produce a “map” of Hepatitis C transmission, linking infections of similar viruses in clusters to identify how the virus has spread.

This web-based platform will help clinicians and epidemiologist access data faster and with less manual processing once the information has been received. It also reduces the cost of molecular testing so that more individuals can be tested and the spread of viral hepatitis can be properly tracked. This model of surveillance may be applied to other infectious diseases in the future. To see the results of this work, please find the poster presentation attached below.

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All The World’s A Sequencer: Global Hepatitis Outbreak Surveillance Technology (GHOST) Cloud Platform

Personalized Medicine

SynVivo

EMS recently formed a partnership with CFDRC and their daughter company, SynVivo. SynVivo develops microfluidic chip technology that recreates the microvascular environment of a patient. Because the cells in a SynVivo chip experiences physical stress from the fluid environment the culture develops in a way that closely resembles a natural system. These cells then show cellular, molecular and drug responses similar to what is observed in vivo.

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